AI Summary
The article discusses a study that found a connection between mitochondrial DNA replication stress and inflammation. The researchers discovered that dysfunctional mitochondrial DNA was being leaked into cells by endosomes responsible for disposing of it. This leakage was causing an inflammatory immune response. The study suggests that targeting this pathway could lead to new therapeutic interventions to disrupt inflammation in aging and disease.
Scientists discovered a pathway from mitochondrial DNA replication stress to immune system activation and inflammation, finding that endosomes responsible for disposing of dysfunctional mitochondrial DNA were leaking mitochondrial DNA into the cell and prompting the inflammatory immune response. The pathway provides new targets for therapeutics that disrupt inflammation during aging and disease.