AI Summary
The content of the article states that there is a non-linear trajectory of prefrontal development in mice during adolescence which involves a reorganization of activity and structure. The authors found that interfering with this development through manipulation of microglia leads to long-lasting disruption of adult network function and cognitive abilities.
Pöpplau et al. uncover a non-linear trajectory of prefrontal development in mice with a major reorganization of activity and structure during adolescence. Interfering with these non-linear dynamics via microglia manipulation results in a long-lasting disruption of adult network function and mPFC-dependent cognitive abilities.