Ovarian adenocarcinoma (OVAD) frequently metastasizes to the peritoneal cavity and manifests by the formation of ascites, which constitutes a tumor-promoting microenvironment . 15(S)-hydroxyeicosatetraenoic acid (HETE), a PPAR ligand, is a critical factor participating in macrophage differentiation and cooperates with CCAAT/enhancer binding protein β (C/EBP&beta)