New type of treatment discovered for attacking fungal infections

A fungus (C. neoformans) grown in three conditions: untreated, treated with a sub-lethal dose of the fatty acid synthase inhibitor NPD6433, and treated with a fluconazole. The number and virulence of fungi were reduced with NPD6433 treatment. Credit: RIKEN

Researchers at the RIKEN Center for Sustainable Research Science (CSRS) and the University of Toronto have discovered a new way to attack fungal infections.

The key is to block fungi from being able to make fatty acids, the major component of fats. Resistance to anti-fungal drugs is increasing and this new approach will be particularly useful because it works

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