Tumor cells use the signaling networks of the G-protein-coupled receptor ( GPCR ) to encourage angiogenesis, growth, and metastasis. We demonstrate how CD8 + T cells are polarized into a dysfunctional state by tumor cells using the GPCR-Gs-protein kinase A( PKA ) signaling axis, limiting tumor infiltration and cytotoxic function of these cells and weakening the effectiveness of current immunotherapies.Access the preview of subscription content here by going to your institution.options for access
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