Actinopyridazone’s entire biosynthetic pathway has been revealed, demonstrating that a novel carrier protein-mediated ring-forming step is essential to its synthesis.
For a variety of medicinal compounds, both natural and synthetic, nitrogen-nitrogen bond-containing cyclic compounds are essential building blocks, including those found in the pyrazole, triazoles, and other compounds. Some of these compounds’ biosynthesis depends on the formation of single bonds between amino acids called nitrogen-nitrogen ( N – N ). The mechanisms by which a variety of compounds can exist, however, are not well understood.
Actinopyridazinone, an N-N bond-containing cyclic compound that serves as a crucial building block for synthetic drugs, was studied in the biosynthetic pathway under the direction of Dr. Kenichi Matsudo and Professor Toshiyuki Wakimoto at Hokkaido