Aging is characterized by a change in signaling pathways that are mediated by neurotransmitters. The coordination chemistry of neurotransmitters is becoming a growing area of interest in understanding signal dysfunction as recent studies have highlighted the important role of transition metal ions, such as Cu ( I / II ), Zn ( III ), and Fe ( ii / III ). In this review, the biological roles of change metal ions and neurotransmitters are discussed, along with the metal-binding characteristics of neuropeptides and small molecule-based transmitters. We also briefly describe the results of their oxidation, polymerization, and aggregation as well as the structural and conformational changes of neurotransmitters caused by redox – active metal ions, such as Cu ( I / II ) and Fe ( Fi / III ). These findings highlight the need for additional study to create possible therapeutic approaches and have significant repercussions for aging.
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