Exploring the antioxidant, antimicrobial, cytotoxic and biothermodynamic properties of novel morpholine derivative bioactive Mn(II), Co(II) and Ni(II) complexes – combined experimental and theoretical measurements towards DNA/BSA/SARS-CoV-2 3CLPro

RSC Medicine Advance Article, 2023, Chem.
DOI: 10.1039/D2MD00394E, Research ArticleOpen access.&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Rui Werner Maçedo Krause, Bienfait Kabuyaya Isamura, and Karunganathan Sakthikumar
Potent DNA cleavage, antimicrobial, and antioxidant activity were provided by the morpholines Mn ( II ), Co ( III ), and Ni( 2 °) and 2, 2′-bipyridine complexes. The results are supported by calculations, with the Co and Ni complexes outperforming cisplatin in terms of anticancer efficacy.
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