According to a recent study published in @ Nature, gut # ILC3( type 3 innate lymphoid cells ) produce IL-2 for # FOXP3 + Tregs. Is it pertinent? Let’s talk about it. https: // t # Immunology # tolerance # microbiota co / iziPJb09ZyDavid Usharauli(@ 3DiMMUNE ) on April 3, 2019.
2. 2. It’s interesting to note that the presence of # microbiota was correlated with the # frequency of IL – 2 producing ILC3s. In particular, the authors demonstrated that # cytokine IL-1, which was produced by # macrophages, signaled ILC3 to produce il-2. # MyD88 was involved( in any case, it is necessary to produce IL-1 ) pic. dGb66Pqnwt on twitter.comDavid Usharauli(@ 3DiMMUNE ) on April 3, 2019.
4.. 4. However, it is evident that IL-2 inactivation in the NCR1-cre mouse is not clean and that some ILC3 still have the ability to secrete the drug( otherwise, this graph shouldn’t contain any ILS-2 + ILP3 ). pic. Zwbz2dDP3n / Twitter.comDavid Usharauli(@ 3DiMMUNE ) on April 3, 2019.
6. 6. The authors also demonstrated that people with # Crohn’s disease have fewer ILC3 that produce IL-2 to feed Tregs in the small intestine, indicating that one reason CDs may cause # inflammatory conditions. pic. twitter.com / k2LN2LeMFeDavid Usharauli(@ 3DiMMUNE ) on April 3, 2019.
In conclusion, this study demonstrated that IL-2 produced by ILC3 could support Treg functionality in the small intestine. As mice with ILC3 deficient for MHCII do not exhibit changes in Tregs, it appears that this cooperation between the two proteins is antigen-nonspecific. 1 / 3David Usharauli(@ 3DiMMUNE ) on April 3, 2019.
I like to draw attention to the fact that only one of the numerous figures depicts a decrease in Treg numbers in the small intestine, supporting the authors’ assertions that IL-2, which is derived from ILC3, is involved in treg homeostasis. The other figures are either shown as %( not ideal) or do not support claims. 3 / 3David Usharauli(@ 3DiMMUNE ) on April 3, 2019.